It is known that the work rolls of rolling mills are subjected to polygonal wear caused by self-excited vibration. To consider countermeasures for this phenomenon, it is necessary to identify the natural frequencies of the rolling mill and evaluate the vibrations during actual operation. Therefore, in this report, to estimate the vibration modes during operation of the rolling mill that lead to polygonal wear of the work rolls, a simulation model was developed coupling Multi-Body Dynamics with rolling theory and a wear model. This model is capable of simultaneously evaluating the behavior of the rolling mill during operation and the progress of wear, taking into account the dynamic model of a four-high rolling mill. This has made it possible to identify the vibration modes that cause roll wear and to consider preventive measures such as structural changes and installation of dampers and monitoring sensors.